Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor | Zendy

Mauro De Santi | Zendy; Giosuè Annibalini | Zendy; Elena Barbieri | Zendy; Anna Villarini | Zendy; Luciana Vallorani | Zendy; Serena Contarelli | Zendy; Franco Berrino | Zendy; Vilberto Stocchi | Zendy; Giorgio Brandi | Zendy

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Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

Author(s) -

Mauro De Santi,

Giosuè Annibalini,

Elena Barbieri,

Anna Villarini,

Luciana Vallorani,

Serena Contarelli,

Franco Berrino,

Vilberto Stocchi,

Giorgio Brandi

Publication year - 2015

Publication title -

cellular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.698

H-Index - 40

eISSN - 2211-3436

pISSN - 2211-3428

DOI - 10.1007/s13402-015-0263-3

Subject(s) - hek 293 cells , cell growth , transfection , cancer research , cancer cell , receptor , cell culture , antibody , immunoprecipitation , breast cancer , cancer , microbiology and biotechnology , biology , immunology , genetics

IGF1 is a key regulator of tissue growth and development and has been implicated in the initiation and progression of various cancers, including breast cancer. Through IGF1 mRNA splicing different precursor pro-peptides, i.e., the IGF1Ea, IGF1Eb and IGF1Ec pro-forms, are formed whose biological roles in the pathogenesis of breast cancer have not been established yet. The objective of this study was to assess the biological activity of the IGF1 pro-forms in human breast cancer-derived cells.

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