Open AccessMass Spectrometric Immunoassay Revisited
Author(s) -
Randall W. Nelson,
Chad R. Borges
Publication year - 2011
Publication title -
journal of the american society for mass spectrometry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1007/s13361-011-0094-z
Subject(s) - chemistry , immunoassay , mass spectrometry , chromatography , matrix assisted laser desorption/ionization , analytical chemistry (journal) , desorption , organic chemistry , adsorption , antibody , immunology , biology
The progressive understanding and improvement of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), realized over the years through the considerable efforts of Dr. Marvin Vestal, have made possible numerous comparable efforts involving its application in the biological sciences. Here we revisit the concepts behind one such analytical approach, Mass Spectrometric Immunoassay, which is designed to selectively detect and quantify proteins present in biological milieu.