The role of BRCA1 in DNA damage response | Zendy

Jiaxue Wu | Zendy; Lin-Yu Lu | Zendy; Xiaochun Yu | Zendy

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The role of BRCA1 in DNA damage response

Author(s) -

Jiaxue Wu,

Lin-Yu Lu,

Xiaochun Yu

Publication year - 2010

Publication title -

protein and cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.973

H-Index - 63

eISSN - 1674-8018

pISSN - 1674-800X

DOI - 10.1007/s13238-010-0010-5

Subject(s) - dna damage , g2 m dna damage checkpoint , dna repair , biology , chek1 , chromatin , genome instability , microbiology and biotechnology , cell cycle checkpoint , cancer research , cell cycle , chromatin remodeling , ubiquitin , dna , genetics , gene

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.

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