Open AccessConsistent tracer administration profile improves test–retest repeatability of myocardial blood flow quantification with 82Rb dynamic PET imaging
Author(s) -
Ran Klein,
Adrian Ocneanu,
Jennifer Renaud,
Maria C. Ziadi,
Rob Beanlands,
Robert A. deKemp
Publication year - 2018
Publication title -
journal of nuclear cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 82
eISSN - 1532-6551
pISSN - 1071-3581
DOI - 10.1007/s12350-016-0698-6
Subject(s) - repeatability , medicine , dipyridamole , blood flow , myocardial perfusion imaging , nuclear medicine , coronary artery disease , perfusion , coronary flow reserve , cardiology , chemistry , chromatography
Quantification of myocardial blood flow (MBF) and stress/rest flow reserve is used increasingly to diagnose multi-vessel coronary artery disease and micro-vascular disease with PET imaging. However, variability in the measurements may limit physician confidence to direct revascularization therapies based on specific threshold values. This study evaluated the effects of rubidium-82 ( 82 Rb) tracer injection profile using a constant-activity-rate (CA) vs a constant-flow-rate (CF) infusion to improve test-retest repeatability of MBF measurements.