Open AccessA pathway map of signaling events triggered upon SARS‐CoV infection
Author(s) -
Parthasarathi K. T. Shreya,
Munjal Nupur S.,
Dey Gourav,
Kumar Abhishek,
Pandey Akhilesh,
Balakrishnan Lavanya,
Sharma Jyoti
Publication year - 2021
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-021-00642-2
Subject(s) - signal transduction , coronavirus , pi3k/akt/mtor pathway , computational biology , biology , covid-19 , bioinformatics , virology , medicine , disease , microbiology and biotechnology , infectious disease (medical specialty) , pathology
Severe acute respiratory syndrome coronaviruses (SARS‐CoVs) caused worldwide epidemics over the past few decades. Extensive studies on various strains of coronaviruses provided a basic understanding of the pathogenesis of the disease. Presently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is leading a global pandemic with unprecedented challenges. This is the third coronavirus outbreak of this century. A signaling pathway map of signaling events induced by SARS‐CoV infection is not yet available. In this study, we present a literature‐annotated signaling pathway map of reactions induced by SARS‐CoV infected cells. Multiple signaling modules were found to be orchestrated including PI3K‐AKT, Ras‐MAPK, JAK‐STAT, Type 1 IFN and NFκB. The signaling pathway map of SARS‐CoV consists of 110 molecules and 101 reactions mediated by SARS‐CoV proteins. The pathway reaction data are available in various community standard data exchange formats including Systems Biology Graphical Notation (SBGN). The pathway map is publicly available through the GitHub repository and data in various formats can be freely downloadable.