Open AccessSARS‐CoV‐2 signaling pathway map: A functional landscape of molecular mechanisms in COVID‐19
Author(s) -
Rex D. A. B.,
Dagamajalu Shobha,
Kandasamy Richard K.,
Raju Rajesh,
Prasad T. S. Keshava
Publication year - 2021
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-021-00632-4
Subject(s) - cytokine storm , signal transduction , coronavirus , pi3k/akt/mtor pathway , medicine , phosphorylation , cell signaling , disease , biology , covid-19 , computational biology , bioinformatics , immunology , microbiology and biotechnology , infectious disease (medical specialty) , pathology
Coronavirus disease (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). COVID‐19 has been declared a pandemic by WHO. The clinical manifestation and disease progression in COVID‐19 patients varies from minimal symptoms to severe respiratory issues with multiple organ failure. Understanding the mechanism of SARS‐CoV‐2 interaction with host cells will provide key insights into the effective molecular targets for the development of novel therapeutics. Recent studies have identified virus‐mediated phosphorylation or activation of some major signaling pathways, such as ERK1/2, JNK, p38, PI3K/AKT and NF‐κB signaling, that potentially elicit the cytokine storm that serves as a major cause of tissue injuries. Several studies highlight the aggressive inflammatory response particularly ‘cytokine storm’ in SARS‐CoV‐2 patients. A depiction of host molecular dynamics triggered by SARS‐CoV‐2 in the form of a network of signaling molecules will be helpful for COVID‐19 research. Therefore, we developed the signaling pathway map of SARS‐CoV‐2 infection using data mined from the recently published literature. This integrated signaling pathway map of SARS‐CoV‐2 consists of 326 proteins and 73 reactions. These include information pertaining to 1,629 molecular association events, 30 enzyme catalysis events, 43 activation/inhibition events, and 8,531 gene regulation events. The pathway map is publicly available through WikiPathways: https://www.wikipathways.org/index.php/Pathway:WP5115 .