Open AccessIs the mechanism of COVID‐19 coagulopathy still a rabbit’s hole?
Author(s) -
Rajan Ashna,
Thirunavukkarasu Ganesh Keshav,
Lockey Richard F.,
Kolliputi Narasaiah
Publication year - 2022
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-021-00613-7
Subject(s) - coagulopathy , covid-19 , medicine , mechanism (biology) , pathophysiology , von willebrand factor , bioinformatics , renin–angiotensin system , complement system , intensive care medicine , immunology , virology , biology , pathology , platelet , disease , antibody , philosophy , epistemology , outbreak , blood pressure , infectious disease (medical specialty)
The pathophysiology of COVID‐19 is an enigma with its severity often determined by the extent of coagulopathy. Several regulatory pathways targeted by the SARS‐CoV‐2 include the renin‐angiotensin system, von Willebrand Factor, and most importantly, the complement pathway. This article discusses these pathways to help design potential future therapies.