Open AccessA comprehensive pathway map of IL‐18‐mediated signalling
Author(s) -
Rex D.A.B,
Agarwal Nupur,
Prasad T. S. Keshava,
Kandasamy Richard K.,
Subbannayya Yashwanth,
Pinto Sneha M.
Publication year - 2020
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-019-00544-4
Subject(s) - proinflammatory cytokine , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , protein kinase b , chemokine , biology , inflammation , immunology
Interleukin‐18 (IL‐18) is a member of the IL‐1 family of cytokines and was initially described as an IFN‐γ‐inducing factor derived from anti‐CD3‐stimulated T‐helper (Th)1 cells. IL‐18 plays a significant role in the activation of hematopoietic cell types mediating both Th1 and Th2 responses and is the primary inducer of interferon‐γ in these cells. The biological activity of IL‐18 is mediated through its binding to the IL‐18 receptor complex and activation of nuclear factor‐κB (NF‐κB), culminating in the production and release of several cytokines, chemokines, and cellular adhesion molecules. In certain cell types, IL‐18 also activates mitogen‐activated protein kinases (MAPKs) and phosphoinositide 3‐kinase/ AKT serine/threonine kinase (PI3K/AKT) signaling modules leading to the production and release of proinflammatory cytokines. IL‐18‐mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration. Albeit its biomedical importance, a comprehensive resource of IL‐18 mediated signaling pathway is currently lacking. In this study, we report on the development of an integrated pathway map of IL‐18/IL‐18R signaling. The pathway map was developed through literature mining from published literature based on manual curation guidelines adapted from NetPath and includes information on 16 protein‐protein interaction events, 38 enzyme‐catalysis events, 12 protein translocation events, 26 activations/inhibition events, transcriptional regulators, 230 gene regulation events and 84 induced protein expression events. The IL‐18 signaling pathway can be freely accessed through the WikiPathways database ( https://www.wikipathways.org/index.php/Pathway:WP4754 ).