Open AccessTwo decades (1998–2018) of research Progress on Hormesis: advancing biological understanding and enabling novel applications
Author(s) -
Kozumbo Walter J.,
Calabrese Edward J.
Publication year - 2019
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-019-00517-7
Subject(s) - hormesis , context (archaeology) , multitude , risk analysis (engineering) , data science , engineering ethics , computer science , medicine , biology , engineering , political science , paleontology , oxidative stress , law , endocrinology
This commentary briefly summarizes the extraordinary resurgence of hormesis within the biological, biomedical, toxicological and risk assessment domains over the past two decades. It places this resurgence within the context of challenging the scientific validity of the threshold and linear dose responses. It argues that conducting research on mechanisms that actuate and regulate the stimulatory response features of hormesis will provide the knowledge needed to develop potentially transformational applications aimed at protecting and enhancing biological resiliency as well as treating/curing a multitude of diverse medical conditions.