Open AccessThe matricellular protein CCN1 in tissue injury repair
Author(s) -
Kim KiHyun,
Won Jong Hoon,
Cheng Naiyuan,
Lau Lester F.
Publication year - 2018
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-018-0450-x
Subject(s) - cyr61 , matricellular protein , wound healing , fibrosis , tissue repair , inflammation , regeneration (biology) , microbiology and biotechnology , medicine , biology , cancer research , ctgf , pathology , receptor , extracellular matrix , immunology , growth factor
The expression of Ccn1 ( Cyr61 ) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including fibrosis and cancer. Recent studies have found that CCN1 plays a critical role in promoting wound healing and tissue repair. Mechanistically, CCN1 functions through direct interaction with specific integrin receptors expressed in various cell types in the wound tissue microenvironment to coordinate diverse cellular functions for repair. Here we briefly summarize the current knowledge on the functions of CCN1 in tissue injury repair and discuss pertinent unanswered questions.