Open AccessThe role of α9β1 integrin and its ligands in the development of autoimmune diseases
Author(s) -
Kon Shigeyuki,
Uede Toshimitsu
Publication year - 2018
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-017-0413-7
Subject(s) - integrin , extracellular matrix , tenascin , rheumatoid arthritis , cell adhesion , immunology , osteopontin , autoimmune disease , microbiology and biotechnology , adhesion , cell adhesion molecule , medicine , biology , cell , chemistry , fibronectin , biochemistry , antibody , organic chemistry
Abstract Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, α9β1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for α9β1 integrin, such as osteopontin and tenascin‐C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between α9β1 integrin and its ligands in the development of autoimmune diseases.