Open AccessCorrelation of Wnt and NOTCH pathways in esophageal squamous cell carcinoma
Author(s) -
Moghbeli Meysam,
Abbaszadegan Mohammad Reza,
Golmakani Ebrahim,
Forghanifard Mohammad Mahdi
Publication year - 2016
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-016-0320-3
Subject(s) - wnt signaling pathway , carcinogenesis , cancer research , notch signaling pathway , metastasis , signal transduction , medicine , correlation , tumor progression , biology , pathology , cancer , microbiology and biotechnology , geometry , mathematics
There is an inevitable association between cell signaling pathways and tumorigenesis. Wnt and notch pathways play important roles during development and self‐renewal. Beside the independent role of such pathways on tumor progression, different cross talks between these pathways through tumorigenesis are emphasized. In this study, we analyzed cross talk between Wnt and NOTCH signaling pathways through assessment of probable correlation between MAML1 and PYGO2 as the main transcription factors of these pathways, respectively in esophageal squamous cell carcinoma (ESCC) patients. Levels of MAML1 and PYGO2 mRNA expression in 48 ESCC patients were compared to the correlated margin normal tissues using real‐time polymerase chain reaction (PCR). Eleven out of 48 patients (22.9 %) have shown the concomitant MAML1/PYGO2 over expression in significant correlation with tumor size ( p = 0.046) and depth of tumor invasion ( p = 0.050). We showed that there is a significant correlation and feedback between these markers during the ESCC progression and metastasis.