Open AccessA pathway map of glutamate metabolism
Author(s) -
Yelamanchi Soujanya D.,
Jayaram Savita,
Thomas Joji Kurian,
Gundimeda Seetaramanjaneyulu,
Khan Aafaque Ahmad,
Singhal Anish,
Keshava Prasad T. S.,
Pandey Akhilesh,
Somani B. L.,
Gowda Harsha
Publication year - 2016
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-015-0315-5
Subject(s) - enzyme , metabolic pathway , biochemistry , regulator , biology , hyperammonemia , metabolism , glutamate synthase , glutamate receptor , chemistry , glutamate dehydrogenase , gene , receptor
Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ‐hydoxybutyric aciduria and 5‐oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post‐translational modifications. This pathway map provides detailed information about enzyme regulation, protein‐enzyme interactions, post‐translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.