Open AccessRole of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion
Author(s) -
Moghbeli Meysam,
Sadrizadeh Ali,
Forghanifard Mohammad Mahdi,
Mozaffari Hooman Mosannen,
Golmakani Ebrahim,
Abbaszadegan Mohammad Reza
Publication year - 2016
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-015-0314-6
Subject(s) - wnt signaling pathway , cancer research , pathology , medicine , catenin , biology , signal transduction , microbiology and biotechnology
Deregulation of developmental signaling pathways such as Wnt/b‐catenin and NOTCH are commonly observed in different cancers. A normal wnt pathway is essential for development and tissue homeostasis to preserve a normal balance between the differentiation and proliferation. PYGO2 is the main transcription factor of wnt pathway, while Msi1 is one of the wnt inhibitors. In this study we assessed the correlation between Msi1 and PYGO2 mRNA expression using Real time polymerase chain reaction in 48 esophageal squamous cell carcinoma (ESCC) patients. Although, there was not any significant correlation between the levels of Msi1 and PYGO2 mRNA expression, we observed a significant correlation between the Msi1 and PYGO2 overexpressed cases and depth of tumor invasion ( p = 0.05). In conclusion, despite the role of these markers in tumor depth of invasion there is not any feedback between Msi1 and PYGO2 gene expression in ESCC.