Open AccessHeparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion
Author(s) -
Brandan Enrique
Publication year - 2015
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-015-0277-7
Subject(s) - heparan sulfate , sulfation , sulfotransferase , progenitor cell , mechanism (biology) , microbiology and biotechnology , sulfate , chemistry , enzyme , biochemistry , glycosaminoglycan , biology , cancer research , stem cell , philosophy , organic chemistry , epistemology
Fast varying 3‐ O ‐sulfated groups in epithelial KIT+ progenitors provides a cellular mechanism to respond to FGFR2b‐mediated signaling and expansion of fetal and adult progenitors. This is allowed by the synthesis of 3‐ O ‐sulfated heparan sulfate that up‐regulate KIT and 3‐ O ‐sulfotransferase enzymes, augmenting 3‐ O ‐sulfated heparan sulfate.