Open AccessEureka! Ets a target for fibrosis!
Author(s) -
Leask Andrew
Publication year - 2011
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-011-0145-z
Subject(s) - bleomycin , fibrosis , transcription factor , lung fibrosis , cancer research , medicine , transforming growth factor , lung , gene , pulmonary fibrosis , bioinformatics , microbiology and biotechnology , biology , genetics , chemotherapy
The oncogenic Ets family of transcription factors is now recognized to play a key role in fibroblasts as it controls the expression of a variety of pro‐fibrotic genes, including the induction of CCN2 by transforming growth factor β. A recent report (Baran et al., Am J Respir Cell Mol Biol. 2011 May 11) shows that mice containing a version of ets2 that is incapable of being phosphorylated are resistant to bleomycin‐induced lung fibrosis. This latter paper is the subject of this commentary.