Open AccessCCN5: biology and pathophysiology
Author(s) -
Russo Joshua W.,
Castellot John J.
Publication year - 2010
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-010-0098-7
Subject(s) - extracellular matrix , pathophysiology , angiogenesis , carcinogenesis , biology , microbiology and biotechnology , computational biology , bioinformatics , cancer , cancer research , genetics , endocrinology
CCN5 is one of six proteins in the CCN family. This family of proteins has been shown to play important roles in many processes, including proliferation, migration, adhesion, extracellular matrix regulation, angiogenesis, tumorigenesis, fibrosis, and implantation. In this review, we focus on the biological and putative pathophysiological roles of CCN5. This intriguing protein is structurally unique among the CCN family members, and has a unique biological activity profile as well.