Open AccessIt’s a knockout: CCN3 suppresses neointimal thickening
Author(s) -
Leask Andrew
Publication year - 2010
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-010-0086-y
Subject(s) - thickening , knockout mouse , in vivo , medicine , cancer research , pathology , biology , chemistry , receptor , genetics , polymer science
The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases.