Open AccessThe role of thrombospondins in wound healing, ischemia, and the foreign body reaction
Author(s) -
Kyriakides Themis R.,
MacLauchlan Susan
Publication year - 2009
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-009-0077-z
Subject(s) - thrombospondins , context (archaeology) , angiogenesis , thrombospondin , matricellular protein , wound healing , thrombospondin 1 , tissue repair , ischemia , regulator , biology , microbiology and biotechnology , extracellular matrix , medicine , immunology , genetics , gene , matrix metalloproteinase , paleontology , metalloproteinase
Thrombospondin (TSP) 1 and TSP2 have been implicated in the regulation of several processes during tissue repair. Due to their matricellular nature, these proteins are thought to modulate cell‐matrix interactions through a variety of mechanisms specific to the spatio‐temporal context of their expression. Most notably, TSP1 and TSP2 appear to play distinct, non‐overlapping roles in the healing of skin wounds. In contrast, both proteins have been implicated as regulators of ischemia‐induced angiogenesis. Moreover, TSP2 has been shown to be a critical regulator of angiogenesis in the foreign body response (FBR). In this review, we discuss the role of TSPs in tissue repair and examine the mechanistic data regarding the ability of the thrombospondins to modulate cell‐matrix interactions in this context.