Open AccessExpression of CCN family of genes in human skin in vivo and alterations by solar‐simulated ultraviolet irradiation
Author(s) -
Quan Taihao,
Shin Sharon,
Qin Zhaoping,
Fisher Gary J.
Publication year - 2009
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-009-0044-8
Subject(s) - in vivo , extracellular matrix , angiogenesis , gene , gene expression , human skin , microbiology and biotechnology , biology , cancer research , chemistry , genetics
The CCN family of proteins is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, and regulation of extracellular matrix. We have investigated expression of CCN family genes and alternations induced by solar‐simulated ultraviolet irradiation in human skin in vivo . Transcripts of all six CCN genes were expressed in human skin in vivo . CCN5 was most abundantly expressed followed by CCN2>CCN3>CCN1>CCN4>CCN6. Solar‐simulated ultraviolet irradiation increased mRNA expression of CCN1 and CCN2. In contrast, mRNA levels of CCN3, CCN4, CCN5, and CCN6, were reduced. Knowledge gained from this study provides the foundation to explore the functional roles of CCN gene products in cutaneous biology and responses to solar ultraviolet irradiation.