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Imipramine is a tricyclic antidepressant that iswidely used for the treatment of major depression. Thereis a possibility that toxic interactions occur followingcombined use of imipramine and intake of alcohol. Inthis study, we investigated the in vitro interactionbetween ethanol and imipramine at high concentrationsby observing a mixed-function oxidation reaction usinghuman liver microsomes. Imipramine and its three mainmetabolites (desipramine; 2-hydroxyimipramine, 2-OHI;2-hydroxydesipramine, 2-OHD) were measured by highperformanceliquid chromatography with ultravioletdetection. The production of 2-OHD, the main metaboliteof imipramine, was signifi cantly inhibited, by 15%–50% (P < 0.05), by ethanol, but that of desipramine or2-OHI was not. These results suggest that enhanced toxicityis attained by simultaneous use of ethanol and highdose of imipramine in the human body

An in vitro study on the interaction between ethanol and imipramine at high concentrations using human liver microsomes