An in vitro study on the interaction between ethanol and imipramine at high concentrations using human liver microsomes | Zendy

Einosuke Tanaka | Zendy; Takako Nakamura | Zendy; Masaru Terada | Zendy; Katsuya Honda | Zendy

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An in vitro study on the interaction between ethanol and imipramine at high concentrations using human liver microsomes

Author(s) -

Einosuke Tanaka,

Takako Nakamura,

Masaru Terada,

Katsuya Honda

Publication year - 2007

Publication title -

forensic toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.105

H-Index - 35

eISSN - 1860-8973

pISSN - 1860-8965

DOI - 10.1007/s11419-007-0036-4

Subject(s) - imipramine , desipramine , chemistry , metabolite , pharmacology , ethanol , tricyclic antidepressant , microsome , in vitro , toxicity , antidepressant , chromatography , medicine , biochemistry , organic chemistry , hippocampus , alternative medicine , pathology

Imipramine is a tricyclic antidepressant that iswidely used for the treatment of major depression. Thereis a possibility that toxic interactions occur followingcombined use of imipramine and intake of alcohol. Inthis study, we investigated the in vitro interactionbetween ethanol and imipramine at high concentrationsby observing a mixed-function oxidation reaction usinghuman liver microsomes. Imipramine and its three mainmetabolites (desipramine; 2-hydroxyimipramine, 2-OHI;2-hydroxydesipramine, 2-OHD) were measured by highperformanceliquid chromatography with ultravioletdetection. The production of 2-OHD, the main metaboliteof imipramine, was signifi cantly inhibited, by 15%–50% (P < 0.05), by ethanol, but that of desipramine or2-OHI was not. These results suggest that enhanced toxicityis attained by simultaneous use of ethanol and highdose of imipramine in the human body

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