Open AccessComposite waves for a cell population system modelling tumor growth and invasion
Author(s) -
Min Tang,
Nicolas Vauchelet,
Ibrahim Cheddadi,
Irène Vig-Clémentel,
Dirk Drasdo,
Benôıt Perthame
Publication year - 2013
Publication title -
hal (le centre pour la communication scientifique directe)
Language(s) - English
DOI - 10.1007/s11401-007-0001-x
Subject(s) - classification of discontinuities , degenerate energy levels , compressibility , mechanics , constant (computer programming) , population , traveling wave , physics , mathematical analysis , mathematics , materials science , computer science , demography , quantum mechanics , sociology , programming language
International audienceThe recent biomechanical theory of cancer growth considers solid tumors as liquid-like materials comprising elastic components. In this fluid mechanical view, the expansion ability of a solid tumor into a host tissue is mainly driven by either the cell diffusion constant or the cell division rate, the latter depending either on the local cell density (contact inhibition), on mechanical stress in the tumor, or both. For the two by two degenerate parabolic/elliptic reaction-diffusion system that results from this modeling, we prove there are always traveling waves above a minimal speed and we analyse their shapes. They appear to be complex with composite shapes and discontinuities. Several small parameters allow for analytical solutions; in particular the incompressible cells limit is very singular and related to the Hele-Shaw equation. These singular traveling waves are recovered numerically