Open AccessPET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis
Author(s) -
Hui Liu,
Hongjun Jin,
Xuyi Yue,
Zonghua Luo,
Chunling Liu,
Adam J. Rosenberg,
Zhude Tu
Publication year - 2016
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-016-0944-y
Subject(s) - experimental autoimmune encephalomyelitis , multiple sclerosis , s1pr1 , spinal cord , lumbar spinal cord , medicine , pathology , olig2 , neuroinflammation , immunohistochemistry , downregulation and upregulation , central nervous system , chemistry , myelin , immunology , oligodendrocyte , vascular endothelial growth factor , biochemistry , disease , psychiatry , vascular endothelial growth factor a , vegf receptors , gene
Upregulation of sphingosine-1-phosphate receptor 1 (S1PR1) expression in multiple sclerosis (MS) lesions is associated with neuroinflammatory response. This study investigated the correlation between neuroinflammation and S1PR1 expression in the spinal cord of an experimental autoimmune encephalomyelitis (EAE) rat model of MS, using the S1PR1 positron emission tomography (PET) radiotracer [(11)C]TZ3321.