Open AccessEvaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging
Author(s) -
Nilantha Bandara,
Alex Zheleznyak,
Kaavya Cherukuri,
David A. Griffith,
Chris Limberakis,
David A. Tess,
Jianqing Chen,
Rikki N. Waterhouse,
Suzanne E. Lapi
Publication year - 2015
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-015-0861-5
Subject(s) - biodistribution , chemistry , glucagon like peptide 1 , receptor , in vivo , peptide , positron emission tomography , nuclear medicine , endocrinology , biochemistry , medicine , in vitro , biology , diabetes mellitus , microbiology and biotechnology , type 2 diabetes
Copper-64 (Cu-64) and Galium-68 (Ga-68) radiolabeled DO3A and NODA conjugates of exendin-4 were used for preclinical imaging of pancreatic β cells via targeting of glucagon-like peptide-1 receptor (GLP-1R).