Species Difference in Intestinal Absorption Mechanism of Etoposide and Digoxin between Cynomolgus Monkey and Rat | Zendy

Tomohiro Nishimura | Zendy; Yukio Kato | Zendy; Naoko Amano | Zendy; Midori Ono | Zendy; Yoshiyuki Kubo | Zendy; Yuka Kimura | Zendy; Hisashi Fujita | Zendy; Akira Tsuji | Zendy

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Species Difference in Intestinal Absorption Mechanism of Etoposide and Digoxin between Cynomolgus Monkey and Rat

Author(s) -

Tomohiro Nishimura,

Yukio Kato,

Naoko Amano,

Midori Ono,

Yoshiyuki Kubo,

Yuka Kimura,

Hisashi Fujita,

Akira Tsuji

Publication year - 2008

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-008-9658-4

Subject(s) - bioavailability , etoposide , pharmacokinetics , pharmacology , p glycoprotein , intestinal permeability , digoxin , efflux , small intestine , chemistry , ussing chamber , endocrinology , biology , medicine , secretion , biochemistry , chemotherapy , heart failure , multiple drug resistance , antibiotics

The oral bioavailability of some therapeutic agents is markedly lower in cynomolgus monkeys than in humans. We investigated small-intestinal absorption of the P-glycoprotein (P-gp) substrates etoposide and digoxin in monkeys to clarify the influence of efflux transport on their intestinal permeability.

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