Open AccessExpanded CD4+ Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma
Author(s) -
Nelli Heikkilä,
Sini M. Laakso,
Helga Mannerström,
Eliisa Kekäläinen,
Päivi Saavalainen,
Hanna Jarva,
T. Petteri Arstila
Publication year - 2016
Publication title -
journal of clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.739
H-Index - 96
eISSN - 1573-2592
pISSN - 0271-9142
DOI - 10.1007/s10875-016-0302-5
Subject(s) - immunology , cytotoxic t cell , biology , cd8 , population , cytokine , transcriptome , interferon gamma , t cell , effector , immune system , gene expression , genetics , medicine , gene , in vitro , environmental health
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare human autoimmune disorder caused by mutations in the AIRE (autoimmune regulator) gene. Loss of AIRE disrupts thymic negative selection and gives rise to impaired cytotoxic and regulatory T cell populations. To date, CD4(+) T helper (Th) cells remain little studied. This study aims to elucidate their role in APECED pathogenesis.
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