Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde | Zendy

Noor Shahina Begum | Zendy; D.E. Vasundhara | Zendy; C. R. Girija | Zendy; Gundurao Kolavi | Zendy; Vinayak Hegde | Zendy; I. M. Khazi | Zendy

Open Access

Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Author(s) -

Noor Shahina Begum,

D.E. Vasundhara,

C. R. Girija,

Gundurao Kolavi,

Vinayak Hegde,

I. M. Khazi

Publication year - 2007

Publication title -

journal of chemical crystallography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.143

H-Index - 34

eISSN - 1572-8854

pISSN - 1074-1542

DOI - 10.1007/s10870-006-9159-4

Subject(s) - monoclinic crystal system , chemistry , substituent , crystal structure , ring (chemistry) , stereochemistry , organometallic chemistry , bicyclic molecule , crystallography , organic chemistry

Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde. The compound crystallizes in the monoclinic space group P21/c with a=17.316(3)Å, b=6.5420(9)Å, c =17.056(3)Å, β=112.909(2)°, V=1779.7(4)Å3, z=4. The, Imidazo[2,1-b][1,3,4] thiadiazole and the coumarin ring systems are each planar but inclined at an angle of 48.14(2)° towards each other. The crystal structure is stabilized by C–H … O interactions

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