Open AccessModeling of a single nanoparticle interaction with the human blood plasma proteins
Author(s) -
Vladas Skakauskas,
Pranas Katauskis
Publication year - 2018
Publication title -
journal of biological physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.318
H-Index - 46
eISSN - 1573-0689
pISSN - 0092-0606
DOI - 10.1007/s10867-018-9509-4
Subject(s) - nanoparticle , human plasma , nanotechnology , chemistry , computational biology , materials science , biology , chromatography
When nanoparticles are introduced into a physiological environment, proteins and lipids immediately cover their surface, forming a protein "corona". It is well recognized that the corona structure influences the biological response of the body. Two deterministic models for corona formation of the human blood serum proteins around a single nanoparticle are presented and studied numerically in this paper. One of them is based on a coupled system of PDEs and involves diffusion of proteins toward the nanoparticle surface. The other one is described by ODEs and is a limit version of the first model as the protein diffusivity tends to infinity. The protein diffusivity influence on the temporal corona structure is studied in detail. Results are presented using figures and discussion.