Open AccessCo-occurrence and metabolic biomarkers of sensory and motor subtypes of peripheral neuropathy from paclitaxel
Author(s) -
Ciao-Sin Chen,
Elizabeth Smith,
Kathleen A. Stringer,
Norah Lynn Henry,
Daniel L Hertz
Publication year - 2022
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-022-06652-x
Subject(s) - medicine , chemotherapy induced peripheral neuropathy , breast cancer , peripheral neuropathy , paclitaxel , sensory system , oncology , cancer , psychology , endocrinology , cognitive psychology , diabetes mellitus
Chemotherapy-induced peripheral neuropathy (CIPN) is the major treatment-limiting toxicity of paclitaxel, which predominantly presents as sensory symptoms, with motor symptoms in some patients. Differentiating CIPN into subtypes has been recommended to direct CIPN research. The objective of this study was to investigate whether sensory and motor CIPN are distinct subtypes with different predictive biomarkers in patients with breast cancer receiving paclitaxel.