BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy | Zendy

Laura Ottini | Zendy; Piera Rizzolo | Zendy; Ines Zanna | Zendy; Mario Falchetti | Zendy; Giovanna Masala | Zendy; Ketty Ceccarelli | Zendy; Vania Vezzosi | Zendy; Alberto Gulino | Zendy; Giuseppe Giannini | Zendy; Simonetta Bianchi | Zendy; Francesco Sera | Zendy; Domenico Palli | Zendy

Open Access

BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy

Author(s) -

Laura Ottini,

Piera Rizzolo,

Ines Zanna,

Mario Falchetti,

Giovanna Masala,

Ketty Ceccarelli,

Vania Vezzosi,

Alberto Gulino,

Giuseppe Giannini,

Simonetta Bianchi,

Francesco Sera,

Domenico Palli

Publication year - 2008

Publication title -

breast cancer research and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.908

H-Index - 154

eISSN - 1573-7217

pISSN - 0167-6806

DOI - 10.1007/s10549-008-0194-z

Subject(s) - male breast cancer , breast cancer , estrogen receptor , population , cancer , ovarian cancer , oncology , medicine , mutation , phenotype , biology , genetics , gene , environmental health

Male breast cancer (MBC) is a rare and scarcely investigated disease. The strongest genetic risk factor for MBC is represented by inherited BRCA2 mutations, whereas the association between MBC and BRCA1 mutations is less clear. MBC appears to be biologically similar to breast cancer in females, however the phenotypic characteristics of BRCA1/2-related MBCs are not yet well elucidated.

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