Open AccessDendritic cells and regulatory T cells in atherosclerosis
Author(s) -
Cheolho Cheong,
JaeHoon Choi
Publication year - 2012
Publication title -
molecules and cells/molecules and cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.665
H-Index - 79
eISSN - 0219-1032
pISSN - 1016-8478
DOI - 10.1007/s10059-012-0128-9
Subject(s) - immune system , immunology , antigen presenting cell , dendritic cell , microbiology and biotechnology , biology , macrophage , antigen , disease , t cell , medicine , pathology , in vitro , biochemistry
Although macrophages and other immune system cells, especially T cells, have been shown to play disease-promoting roles in atherosclerosis, less is known about the role of antigen presenting cells. Functional, immune stimulating dendritic cells (DCs) have recently been detected in aortic intima, the site of origin of atherosclerosis. We had compared DCs with macrophages in mice with experimental atherosclerosis, to clearly define cell types by developmental and functional criteria. This review summarizes recent advances in studies of DCs in humans and in mouse models of atherosclerosis, as well as providing a simple strategy to measure regulatory T (Treg) cells in the mouse aorta.