z-logo
open-access-imgOpen Access
Regulation of the Female Rat Estrous Cycle by a Neural Cell-Specific Epidermal Growth Factor-like Repeat Domain Containing Protein, NELL2
Author(s) -
Beyong Hwan Ryu,
Han Rae Kim,
Jin Kwon Jeong,
Byung Ju Lee
Publication year - 2011
Publication title -
molecules and cells/molecules and cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.665
H-Index - 79
eISSN - 0219-1032
pISSN - 1016-8478
DOI - 10.1007/s10059-011-0086-7
Subject(s) - estrous cycle , medicine , endocrinology , estrogen , biology , preoptic area , hypothalamus , epidermal growth factor , ovariectomized rat , arcuate nucleus , lordosis behavior , hormone , receptor , estradiol benzoate
NELL2, a protein containing epidermal growth factor-like repeat domains, is predominantly expressed in the nervous system. In the mammalian brain, NELL2 expression is mostly neuronal. Previously we found that NELL2 is involved in the onset of female puberty by regulating the release of gonadotropin-releasing hormone (GnRH), and in normal male sexual behavior by controlling the development of the sexually dimorphic nucleus of the preoptic area (POA). In this study we investigated the effect of NELL2 on the female rat estrous cycle. NELL2 expression in the POA was highest during the proestrous phase. NELL2 mRNA levels in the POA were increased by estrogen treatment in ovariectomized female rats. Blocking NELL2 synthesis in the female rat hypothalamus decreased the expression of kisspeptin 1, an important regulator of the GnRH neuronal apparatus, and resulted in disruption of the estrous cycle at the diestrous phase. These results indicate that NELL2 is involved in the maintenance of the normal female reproductive cycle in mammals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here