Open AccessGenetics of developmental dyslexia
Author(s) -
Thomas Scerri,
Gerd SchulteKörne
Publication year - 2009
Publication title -
european child and adolescent psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.796
H-Index - 93
eISSN - 1435-165X
pISSN - 1018-8827
DOI - 10.1007/s00787-009-0081-0
Subject(s) - dyslexia , candidate gene , biology , developmental dyslexia , genetics , genome wide association study , foxp2 , gene , psychology , evolutionary biology , genotype , single nucleotide polymorphism , reading (process) , transcription factor , law , political science
Developmental dyslexia is a highly heritable disorder with a prevalence of at least 5% in school-aged children. Linkage studies have identified numerous loci throughout the genome that are likely to harbour candidate dyslexia susceptibility genes. Association studies and the refinement of chromosomal translocation break points in individuals with dyslexia have resulted in the discovery of candidate genes at some of these loci. A key function of many of these genes is their involvement in neuronal migration. This complements anatomical abnormalities discovered in dyslexic brains, such as ectopias, that may be the result of irregular neuronal migration.
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