EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts | Zendy

Jenny ZweiChieng Chang | Zendy; WanHsien Yang | Zendy; Yiting Deng | Zendy; HsinMing Chen | Zendy; Mark YenPing Kuo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts

Author(s) -

Jenny ZweiChieng Chang,

WanHsien Yang,

Yiting Deng,

HsinMing Chen,

Mark YenPing Kuo

Publication year - 2012

Publication title -

clinical oral investigations

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.088

H-Index - 82

eISSN - 1436-3771

pISSN - 1432-6981

DOI - 10.1007/s00784-012-0713-5

Subject(s) - ctgf , p38 mitogen activated protein kinases , kinase , mapk/erk pathway , transforming growth factor , signal transduction , microbiology and biotechnology , growth factor , protein kinase a , chemistry , biology , biochemistry , receptor

Transforming growth factor β (TGFβ) has been suggested as the main trigger for the increased collagen production and decreased matrix degradation pathways in oral submucous fibrosis (OSF). Connective tissue growth factor (CTGF/CCN2) and cyclooxygenase-2 (COX-2) were found to overexpress in OSF. The aim of this study was to investigate the molecular mechanism underlying the TGFβ-induced CCN2 expressions in human buccal mucosal fibroblasts (BMFs) to identify the potential targets for drug intervention or chemoprevention of OSF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research