High incidence of elevated antibody titers to Epstein-Barr virus in patients with uveitis | Zendy

Chizu Touge | Zendy; Hideyuki Agawa | Zendy; Takeshi Sairenji | Zendy; Yoshitsugu Inoue | Zendy

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High incidence of elevated antibody titers to Epstein-Barr virus in patients with uveitis

Author(s) -

Chizu Touge,

Hideyuki Agawa,

Takeshi Sairenji,

Yoshitsugu Inoue

Publication year - 2005

Publication title -

archives of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.943

H-Index - 110

eISSN - 1432-8798

pISSN - 0304-8608

DOI - 10.1007/s00705-005-0686-7

Subject(s) - virology , biology , medical microbiology , titer , virus , incidence (geometry) , antibody , uveitis , antibody titer , immunology , physics , optics

We assayed Epstein-Barr virus (EBV) antibody titers in patients' sera using indirect immunofluorescence and tested for the presence of antibody to EBV immediate-early BZLF1 protein ZEBRA by Western blotting to explore the association of EBV infection with uveitis. IgG and IgA antibodies to viral capsid antigen (VCA), IgG antibodies to early antigen (EA), and antibodies to EBV nuclear antigen were detected at higher titers in sera of patients with uveitis than in the sera of healthy controls. Neither IgM antibody to VCA nor EA was detected in the patients' sera. Anti-ZEBRA-IgG antibodies were detected in most patients' sera, but not in those of healthy controls. These results suggest that uveitis might be a disease accompanied by EBV reactivation.

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