Open AccessSOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model
Author(s) -
Kumi Mesaki,
Masaomi Yamane,
Seiichiro Sugimoto,
Masayoshi Fujisawa,
Teizo Yoshimura,
Takeshi Kurosaki,
Shinji Otani,
Shinichiro Miyoshi,
Takahiro Oto,
Akihiro Matsukawa,
Shinichi Toyooka
Publication year - 2019
Publication title -
surgery today
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 63
eISSN - 1436-2813
pISSN - 0941-1291
DOI - 10.1007/s00595-018-1753-5
Subject(s) - medicine , transplantation , socs3 , bronchiolitis obliterans , cytokine , lung transplantation , genetically modified mouse , immunology , cancer research , transgene , pathology , biology , gene , biochemistry , cancer , suppressor
Suppressor of cytokine signaling-3 (SOCS3) is a negative feedback inhibitor of cytokine signaling with T-cell-mediated immunosuppressive effects on obliterative bronchiolitis (OB). In this study, we aimed to investigate the impact of T-cell-specific overexpression of SOCS3 using a murine heterotopic tracheal transplantation (HTT) model.
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