Open AccessMyotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia
Author(s) -
Sachiko Otsuki,
Toshimichi Yasuda,
Keiko Mukaida,
Yuko Noda,
Rieko Kanzaki,
Hirotsugu Miyoshi,
Takashi Kondo,
Hiroshi Hamada,
Masashi Kawamoto
Publication year - 2018
Publication title -
journal of anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.599
H-Index - 44
eISSN - 1438-8359
pISSN - 0913-8668
DOI - 10.1007/s00540-018-2526-4
Subject(s) - malignant hyperthermia , myotoxin , medicine , lidocaine , anesthesia , levobupivacaine , skeletal muscle , calcium in biology , pharmacology , bupivacaine , calcium , chemistry , biochemistry , phospholipase a2 , enzyme
Malignant hyperthermia (MH) is an inherited muscle disorder caused by abnormal elevations of intracellular calcium (Ca 2+ ) in skeletal muscle. There are several reports of myotoxicity caused by local anesthetics, and the increased intracellular Ca 2+ is considered to be an important cause. However, there is insufficient evidence regarding myotoxicity in MH-susceptible individuals when large doses of local anesthetics are administered. This study investigated the effect of MH predisposition on myotoxicity.
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