Magnesium sulfate attenuates tourniquet pain in healthy volunteers | Zendy

Tsuyoshi Satsumae | Zendy; Hiroshi Yamaguchi | Zendy; Shinichi Inomata | Zendy; Makoto Tanaka | Zendy

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Magnesium sulfate attenuates tourniquet pain in healthy volunteers

Author(s) -

Tsuyoshi Satsumae,

Hiroshi Yamaguchi,

Shinichi Inomata,

Makoto Tanaka

Publication year - 2012

Publication title -

journal of anesthesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.599

H-Index - 44

eISSN - 1438-8359

pISSN - 0913-8668

DOI - 10.1007/s00540-012-1493-4

Subject(s) - tourniquet , medicine , anesthesia , nmda receptor , saline , magnesium , blood pressure , receptor , chemistry , organic chemistry

Preoperative administration of an N-methyl-D-aspartate (NMDA) receptor antagonist has been shown to attenuate tourniquet-induced blood pressure increase under general anesthesia, suggesting that the mechanism of this blood pressure increase includes NMDA receptor activation. The attenuation of this increase may be associated with the pain relief induced by NMDA receptor antagonism. We tested the hypothesis that magnesium sulfate, an NMDA receptor antagonist, attenuates tourniquet pain.

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