Blockade of the apelin–APJ system promotes mouse liver regeneration by activating Kupffer cells after partial hepatectomy | Zendy

Shohei Yoshiya | Zendy; Ken Shirabe | Zendy; Daisuke Imai | Zendy; Takeo Toshima | Zendy; Yoichi Yamashita | Zendy; Toru Ikegami | Zendy; Shinji Okano | Zendy; Tomoharu Yoshizumi | Zendy; Hirofumi Kawanaka | Zendy; Yoshihiko Maehara | Zendy

Open Access

Blockade of the apelin–APJ system promotes mouse liver regeneration by activating Kupffer cells after partial hepatectomy

Author(s) -

Shohei Yoshiya,

Ken Shirabe,

Daisuke Imai,

Takeo Toshima,

Yoichi Yamashita,

Toru Ikegami,

Shinji Okano,

Tomoharu Yoshizumi,

Hirofumi Kawanaka,

Yoshihiko Maehara

Publication year - 2014

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 114

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s00535-014-0992-5

Subject(s) - liver regeneration , hepatectomy , tumor necrosis factor alpha , medicine , kupffer cell , endocrinology , regeneration (biology) , apelin , receptor , cancer research , biology , microbiology and biotechnology , surgery , resection

Liver regeneration after massive hepatectomy or living donor liver transplantation is critical. The apelin-APJ system is involved in the regulation of cardiovascular function, inflammation, fluid homeostasis, the adipo-insular axis, and angiogenesis, but its function in liver regeneration remains unclear.

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