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Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor
Author(s) -
Kosuke Takagaki,
Satoshi Osawa,
Yoshiaki Horio,
Takanori Yamada,
Yasushi Hamaya,
Yasuhiro Takayanagi,
Takahisa Furuta,
Akira Hishida,
Mutsuhiro Ikuma
Publication year - 2009
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-009-0019-9
Subject(s) - histamine , dimaprit , thioperamide , cytokine , histamine h4 receptor , histamine h2 receptor , histamine receptor , intraepithelial lymphocyte , histamine h1 receptor , biology , splenocyte , immunology , chemistry , immune system , receptor , endocrinology , antagonist , biochemistry
Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal intraepithelial lymphocytes (IELs), the front line of the intestinal mucosal immune system, is not well understood. We examined whether histamine has a direct effect on cytokine production by IELs and the involvement of histamine receptor subtypes.

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