Open AccessIntracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats
Author(s) -
Hiroto Yamada,
Satoshi Tanno,
Kaoru Takakusaki,
Toshikatsu Okumura
Publication year - 2007
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-007-2007-2
Subject(s) - orexin a , orexin , muscarinic acetylcholine receptor , atropine , endocrinology , pharmacology , medicine , intraperitoneal injection , receptor , neuropeptide , chemistry
Accumulating evidence indicates that orexin-A in the brain stimulates vagal flow projecting to the stomach. Since the vagal system plays an important role in gastric mucosal integrity, we hypothesized that orexin-A in the brain might have a gastroprotective action.
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