Open AccessIdentification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer
Author(s) -
Levent Beder,
Mehmet Gündüz,
Mamoru Ouchida,
Esra Gündüz,
Akiko Sakai,
Kunihiro Fukushima,
Hitoshi Nagatsuka,
Sachio Ito,
Noriyasu Honjo,
Kazunori Nishizaki,
Kenji Shimizu
Publication year - 2005
Publication title -
journal of cancer research and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 94
eISSN - 1432-1335
pISSN - 0171-5216
DOI - 10.1007/s00432-005-0033-0
Subject(s) - loss of heterozygosity , biology , carcinogenesis , haploinsufficiency , gene , tumor suppressor gene , head and neck squamous cell carcinoma , cancer research , allele , genetics , cancer , head and neck cancer , phenotype
Aims of the study are to narrow-down the hotspot region on 10q21 defined by previous genome-wide loss of heterozygosity (LOH) analysis in head and neck squamous cell carcinomas (HNSCC) and to define candidate tumor suppressor genes (TSG) concerned with 10q21.
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