Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart | Zendy

Rubén TorregrosaMuñumer | Zendy; Elena Vara | Zendy; Jesús Ángel Fernández-Tresguerres | Zendy; Ricardo Gredilla | Zendy

Open Access

Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart

Author(s) -

Rubén TorregrosaMuñumer,

Elena Vara,

Jesús Ángel Fernández-Tresguerres,

Ricardo Gredilla

Publication year - 2021

Publication title -

european journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.321

H-Index - 96

eISSN - 1436-6215

pISSN - 1436-6207

DOI - 10.1007/s00394-020-02457-0

Subject(s) - resveratrol , oxidative stress , inflammation , nitric oxide , apoptosis , antioxidant , senescence , pharmacology , nitric oxide synthase , medicine , endocrinology , biology , biochemistry

Aging is known to play a critical role in the etiopathogenesis of several diseases. Among them, cardiovascular disorders are especially relevant since they are becoming the first cause of death in western countries. Resveratrol is a polyphenolic compound that has been shown to exert beneficial effects at different levels, including neuronal and cardiovascular protection. Those effects of resveratrol are related, at least in part, to its antioxidant and anti-inflammatory properties. In the current investigation we were interested in exploring whether the positive effects of resveratrol at cardiac level were taking place even when the supplementation started in already old animals.

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