Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis | Zendy

Hideki Nakamura | Zendy; Akitomo Okada | Zendy; Atsushi Kawakami | Zendy; Satoshi Yamasaki | Zendy; Hiroaki Ida | Zendy; Masakatsu Motomura | Zendy; Daisuke Imanishi | Zendy; Katsumi Eguchi | Zendy

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Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis

Author(s) -

Hideki Nakamura,

Akitomo Okada,

Atsushi Kawakami,

Satoshi Yamasaki,

Hiroaki Ida,

Masakatsu Motomura,

Daisuke Imanishi,

Katsumi Eguchi

Publication year - 2009

Publication title -

rheumatology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 74

eISSN - 1437-160X

pISSN - 0172-8172

DOI - 10.1007/s00296-009-1113-2

Subject(s) - medicine , pure red cell aplasia , myasthenia gravis , isoniazid , aplasia , complication , bone marrow aplasia , aplastic anemia , systemic lupus erythematosus , autoimmune hemolytic anemia , anemia , gastroenterology , rheumatology , plasmapheresis , bone marrow , immunology , dermatology , pathology , antibody , tuberculosis , disease

A 47-year-old woman who had been treated for systemic lupus erythematosus (SLE) with myasthenia gravis (MG) was admitted to our hospital with acute onset of severe anemia after administration of isoniazid. Pure red cell aplasia (PRCA) was confirmed by elevated serum iron levels, reticulocytopenia and bone marrow aspiration showing a remarkable reduction of erythroblasts. Finally, cyclosporine A successfully improved PRCA. Although both SLE and MG have the potential complication of PRCA, we report here a case of isoniazid-triggered PRCA.

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