Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice | Zendy

Viviane Costa Junqueira Rocha | Zendy; Luciana Souza de Aragão França | Zendy; Cintia Figueiredo de Araújo | Zendy; Ayling Martins Ng | Zendy; Candace Machado de Andrade | Zendy; André Cronemberger Andrade | Zendy; Emanuelle de Souza Santos | Zendy; Mariana da Cruz Borges-Silva | Zendy; Simone Garcia Macambira | Zendy; Alberto A. Noronha-Dutra | Zendy; Lain Carlos Pontes-de-Carvalho | Zendy

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Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice

Author(s) -

Viviane Costa Junqueira Rocha,

Luciana Souza de Aragão França,

Cintia Figueiredo de Araújo,

Ayling Martins Ng,

Candace Machado de Andrade,

André Cronemberger Andrade,

Emanuelle de Souza Santos,

Mariana da Cruz Borges-Silva,

Simone Garcia Macambira,

Alberto A. Noronha-Dutra,

Lain Carlos Pontes-de-Carvalho

Publication year - 2015

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-015-2949-7

Subject(s) - cardiotoxicity , doxorubicin , lipid peroxidation , malondialdehyde , pharmacology , saline , medicine , intraperitoneal injection , body weight , toxicity , creatine kinase , chemotherapy , oxidative stress , endocrinology

Doxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice.

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