Open AccessSatraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance
Author(s) -
Murugan Kalimutho,
Antonella Minutolo,
Sandro Grelli,
Amanda Formosa,
Giulia Maria Sancesario,
Alessandra Valentini,
Giorgio Federici,
Sergio Bernardini
Publication year - 2010
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-010-1428-4
Subject(s) - oxaliplatin , apoptosis , cancer research , cell cycle checkpoint , cell cycle , programmed cell death , cancer cell , colorectal cancer , chemistry , cancer , pharmacology , biology , medicine , biochemistry
Satraplatin acts as a potent inhibitor of proliferation in castration-resistant prostate cancer, yet the basic and molecular pharmacological mechanisms are still unknown in all types of cancer including colorectal cancer (CRC). In an effort to explain the mechanism of tumour sensitivity to satraplatin, the cytotoxic effects in a panel of CRC cell lines was examined with regard to their p53 genotype in comparison with oxaliplatin.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom