Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder | Zendy

Joachim Vandepitte | Zendy; Ben Van Cleynenbreugel | Zendy; Klaudia Hettinger | Zendy; Hendrik Van Poppel | Zendy; Peter de Witte | Zendy

Open Access

Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder

Author(s) -

Joachim Vandepitte,

Ben Van Cleynenbreugel,

Klaudia Hettinger,

Hendrik Van Poppel,

Peter de Witte

Publication year - 2010

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-010-1375-0

Subject(s) - hypericin , urothelium , biodistribution , photodynamic therapy , urinary bladder , pathology , chemistry , urology , medicine , pharmacology , biochemistry , organic chemistry , in vitro

In this preclinical study, we examined the biodistribution of hypericin formulated as its water-soluble PVP-hypericin complex in the different layers (urothelium, submucosa, muscle) of a normal rat bladder and a rat bladder bearing a malignant urothelium composed of syngeneic AY-27 tumor cells. The results were compared with the biodistribution of hexaminolevulinate (HAL)-induced protoporphyrin IX (PpIX).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research