Open AccessThe BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid
Author(s) -
Antonello A. Romani,
Silvia Desenzani,
Marina Morganti,
Maria Cristina Baroni,
Angelo F. Borghetti,
Paolo Soliani
Publication year - 2010
Publication title -
cancer chemotherapy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.112
H-Index - 111
eISSN - 1432-0843
pISSN - 0344-5704
DOI - 10.1007/s00280-010-1345-6
Subject(s) - apoptosis , cancer research , cell culture , poly adp ribose polymerase , caspase 3 , in vivo , cytotoxic t cell , chemistry , intrinsic apoptosis , caspase , programmed cell death , biology , in vitro , biochemistry , dna , genetics , microbiology and biotechnology , polymerase
In TFK-1 and EGI-1 cholangiocarcinoma cell lines, zoledronic acid (ZOL) determines an S-phase block without apoptosis. Here, we investigated the occurrence of apoptosis stigmata when ZOL is associated to the BH3-mimetic ABT-737.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom