A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells | Zendy

Andrew J. Massey | Zendy; D.S. Williamson | Zendy; Helen Browne | Zendy; James B. Murray | Zendy; P. Dokurno | Zendy; T. Shaw | Zendy; Alba T. Macias | Zendy; Zoe Daniels | Zendy; Stephanie Geoffroy | Zendy; Melanie Dopson | Zendy; Paul Lavan | Zendy; Natalia Matassova | Zendy; Geraint L. Francis | Zendy; Christopher J Graham | Zendy; Rachel Parsons | Zendy; Yikang Wang | Zendy; Antony Padfield | Zendy; M.Margaret Comer | Zendy; Martin J. Drysdale | Zendy; Mike Wood | Zendy

Open Access

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Author(s) -

Andrew J. Massey,

D.S. Williamson,

Helen Browne,

James B. Murray,

P. Dokurno,

T. Shaw,

Alba T. Macias,

Zoe Daniels,

Stephanie Geoffroy,

Melanie Dopson,

Paul Lavan,

Natalia Matassova,

Geraint L. Francis,

Christopher J Graham,

Rachel Parsons,

Yikang Wang,

Antony Padfield,

M.Margaret Comer,

Martin J. Drysdale,

Mike Wood

Publication year - 2009

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-009-1194-3

Subject(s) - apoptosis , hsp90 , heat shock protein , hsp70 , hsp90 inhibitor , cell culture , biology , cell growth , cancer research , cancer cell , caspase , programmed cell death , chemistry , microbiology and biotechnology , biochemistry , cancer , genetics , gene

The anti-apoptotic function of the 70 kDa family of heat shock proteins and their role in cancer is well documented. Dual targeting of Hsc70 and Hsp70 with siRNA induces proteasome-dependent degradation of Hsp90 client proteins and extensive tumor specific apoptosis as well as the potentiation of tumor cell apoptosis following pharmacological Hsp90 inhibition.

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