DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma | Zendy

Rikke Lindgaard Hedeland | Zendy; Kristian Hvidt | Zendy; Jacob Nersting | Zendy; Susanne Rosthøj | Zendy; Kim Dalhoff | Zendy; Birgitte Lausen | Zendy; Kjeld Schmiegelow | Zendy

Open Access

DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma

Author(s) -

Rikke Lindgaard Hedeland,

Kristian Hvidt,

Jacob Nersting,

Susanne Rosthøj,

Kim Dalhoff,

Birgitte Lausen,

Kjeld Schmiegelow

Publication year - 2009

Publication title -

cancer chemotherapy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.112

H-Index - 111

eISSN - 1432-0843

pISSN - 0344-5704

DOI - 10.1007/s00280-009-1184-5

Subject(s) - hodgkin lymphoma , acute lymphocytic leukemia , lymphoma , medicine , childhood leukaemia , maintenance therapy , nucleotide , lymphoblastic lymphoma , chemotherapy , lymphoblastic leukemia , cancer research , immunology , oncology , leukemia , pediatrics , biology , genetics , gene , immune system , t cell

To explore the DNA incorporation of 6-thioguanine nucleotide levels (DNA-6TGN) during 6-mercaptopurine (6MP) therapy of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) and its relation to erythrocyte levels of their metabolites: 6-thioguanine-nucleotides (E-6TGN), methylated metabolites (E-MeMP), Methotrexate polyglutamates (E-MTX), and to thiopurine methyltransferase activity (TPMT).

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